EA Post Approval, Mulitcenter, Open-Label, Longitudinal, Uncontrolled Safety Study of Cosmetic Tissue Augmentation Product (ELEVESS) in the Treatment of Nasolabial Folds in People of Color
Participants receive correction of deep nasolabial folds with an FDA approved cosmetic tissue augmentation device at no cost.

Efficacy and Safety of Altretinoin in the Treatment of Severe Chronic Hand Eczema refractory to Topical Therapy
Participants will receive standard skin care and treatment with potent topical corticosteroids.

Appetite-Related Sensations Study
This study will look into the reactions to an investigational drug on appetite-related senations in healthy women.

Investigational Medication for Primary Biliary Cirrhosis (PBC)
This study evaluates the safety, tolerability and effectiveness of an investigational medication for PBC in people who are currently taking ursodeoxycholic acid (URSO, UDCA) and have an increased alkaline phosphatase (AP) blood level for at least 6 months.

Hepatitis B in Black/African-Americans and Hispanic Patients
The Division of Digestive Diseases is conducting a clinical study to test an investigational medicine for treatment of chronic hepatitis B infection in Black/African-American and Hispanic patients who never been treated for their hepatitis B infection

Study of Entecavir in Patients with Chronic Hepatitis B Virus (HBV) Infection
The Division of Digestive Diseases is conducting a clinical study to assess the long-term outcomes (benefits and risks) associated with entecavir (ETV) therapy as compared to other hepatitis B medication approved for the treatment of chronic HBV infection.

ENdoscopic ABlation using Light Energy (ENABLE)
This study seeks to determine if surgical anastomosis of the superficial temporal artery to the middle cerebral artery (STA-MCA) combined with best medical therapy can reduce subsequent strokes at two years by 40%. Eligible participants must have internal carotid artery occlusion producing hemispheric symptoms within the previous 120 days and ipsilateral increased oxygen extraction fraction measured by positron emission tomography (PET).

Carotid Occlusion Surgery
This study seeks to determine if surgical anastomosis of the superficial temporal artery to the middle cerebral artery (STA-MCA) combined with best medical therapy can reduce subsequent strokes at two years by 40%. Eligible participants must have internal carotid artery occlusion producing hemispheric symptoms within the previous 120 days and ipsilateral increased oxygen extraction fraction measured by positron emission tomography (PET).